Despite New Results - Keep Eating Your Fruits and Vegetables

The headlines this week about fruits and vegetables doing little, if anything, to lower cancer risk may entice you to reach for a candy bar rather than a carrot (study), but there's still plenty of good reasons to keep working on your 5 or more each day.

Most importantly, there's still very good evidence that eating a diet rich in fruits and vegetables can significantly lower the risk of heart disease and stroke - two major killers in the United States.  One 2004 study that included over 70,000 participants from the Nurses' Health Study and over 35,000 participants from Health Professionals Follow-Up Study found that those people eating eight or more servings of fruits and vegetables per day had a 30 percent lower risk of cardiovascular disease than those eating less than 1.5 servings per day (study) (1).  On top of this, studies also strongly suggest that a diet high in plant foods can lower the risk of diabetes and high blood pressure (2,3), and help keep weight in check (4,5).

In terms of cancer risk, while it's true that the recent study out of Europe that included over 400,000 people followed over eight years found only a very small benefit from eating fruits and vegetables, it's important to keep some things in mind when looking at these results (6).

First, they don't rule out a benefit for specific cancers from eating specific fruits and vegetables.  It can get fairly complicated, fairly quickly, but the European study looked at links between overall cancer risk and overall fruit and vegetable intake.  Yet, there is good evidence that some certain types of fruits and vegetables may lower the risk of some certain types of cancer.  For example, diets high in tomato-based foods have been found in previous studies to lower the risk of prostate cancer and diets rich in yellow/orange vegetables have been found to lower the risk of lung cancer (7-9).  The broad approach of the European study could have washed out such targeted benefits.

Second, the study only looked at adult intake of fruit and vegetables.  One thing that's become clear over the years is that when a person is exposed to a factor can have important implications on how it affects cancer risk. The time frame for prevention matters.  Radiation is one good example, and one mentioned in the editorial accompanying the study (editorial) (10).  The younger a person is when exposed to a given amount of radiation, the greater the impact that exposure will have on later cancer risk.  Soy intake and breast cancer risk is another prime example, with studies showing that the reduced risk linked to high soy intake may be strongest for intake in childhood and adolescence (11). The relationship could be similar with fruits and vegetables.  Eating a diet rich in fruits and vegetables early in life could have a much bigger impact on lowering cancer risk than such a diet later in life.  Looking at diet so late and only a few years before cancer is diagnosed may be looking in the wrong place. (See related post).

The results of this new study are little surprise to the scientific community, who have seen the cancer benefits of total fruit and vegetable consumption dwindle as good evidence has accumulated over the past ten years.  Yet, the overall health benefits of a diet rich in fruits and vegetables aren't in question when you look beyond cancer to heart disease, stroke, diabetes, and weight control.

To get the most out of the produce aisle: 
  • Eat at least 5 servings of fruits and vegetables a day
  • Choose a good variety of all different colors.  Don't be afraid to try something new.
  • Be a good example for your kids and grandkids. Encourage them from a young age to make fruits and vegetables a main part of what they eat each day.


Related CNiC post
Adolescent diet prevents breast cancer - March 18, 2010

Literature cited
  1. Hung, H.C., et al., Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst, 2004. 96(21): p. 1577-84.
  2. Schulze, M.B., et al., Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women. Am J Clin Nutr, 2004. 80(2): p. 348-56.
  3. Appel, L.J., et al., A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group [see comments]. N Engl J Med, 1997. 336(16): p. 1117-24.
  4. Vioque, J., et al., Intake of fruits and vegetables in relation to 10-year weight gain among Spanish adults. Obesity (Silver Spring), 2008. 16(3): p. 664-70.
  5. He, K., et al., Changes in intake of fruits and vegetables in relation to risk of obesity and weight gain among middle-aged women. Int J Obes Relat Metab Disord, 2004. 28(12): p. 1569-74.
  6. Boffetta, P., et al., Fruit and Vegetable Intake and Overall Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst, 2010.
  7. Feskanich, D., et al., Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. J Natl Cancer Inst, 2000. 92(22): p. 1812-23.
  8. Ruano-Ravina, A., A. Figueiras, and J.M. Barros-Dios, Diet and lung cancer: a new approach. Eur J Cancer Prev, 2000. 9(6): p. 395-400.
  9. Agarwal, S. and A.V. Rao, Tomato lycopene and its role in human health and chronic diseases. CMAJ, 2000. 163(6): p. 739-44.
  10. Willett, W.C., Fruits, Vegetables, and Cancer Prevention: Turmoil in the Produce Section. J Natl Cancer Inst, 2010.
  11. Wu, A.H., et al., Epidemiology of soy exposures and breast cancer risk. Br J Cancer, 2008. 98(1): p. 9-14.
  12. Agarwal, S. and A.V. Rao, Tomato lycopene and its role in human health and chronic diseases. CMAJ, 2000. 163(6): p. 739-44.

Health care reform and prevention of cancer

In Sunday's New York Times (story), Robert Pear wrote about the many disease prevention initiatives contained in the new health care law recently passed by congress and signed by the president. It's important to stop and consider the full implications of this. 

Importantly, Medicaid will now cover drugs and counseling to help pregnant women stop smoking. This will have substantial public health benefit. Worksites allowing a reasonable break time for nursing mothers to either nurse of pump milk will not only be of benefit for the infant being breastfed but also for the mother, as longer durations of breastfeeding significantly reduce risk of ovarian cancer and breast cancer. This long term benefit to new mothers is often overlooked in policy debates.

Access to screening is also positioned as a benefit of the new law. Yet, we should not forget that access alone does not remove disparities in the cancer burden. Strong evidence from Medicare shows that with access to colon cancer screening in place, levels of screening have risen over time. Importantly this increase has been observed across race and education levels. However, significantly lower rates of screening for colorectal cancer are observed among less educated older adults. As of 2005 among Medicare beneficiaries, rates of colon cancer screening were 20 percent lower among those with a less-than-high school education compared to those with a greater-than-high school education (study link) (1). Similar disparities were observed by income level.  

The clear message is that we must continue to focus prevention messages and strategies on ways to reach such groups so they too can gain the benefits of cancer prevention through colorectal screening. We cannot ignore the powerful data that come from Medicare through the past decade. Prevention efforts must focus on strategies that bring participation in prevention to a common level across society. Only then will we achieve the benefits of wellness for all regardless of age, education and income.

For more on cancer prevention, see: http://knol.google.com/k/cancer-prevention#

Literature cited
  1. Doubeni, C.A., et al., Socioeconomic and racial patterns of colorectal cancer screening among Medicare enrollees in 2000 to 2005. Cancer Epidemiol Biomarkers Prev, 2009. 18(8): p. 2170-5.

More Blistering Truths About Tanning Bed Use By Youth

A new study published online last week in the British Medical Journal on tanning bed use by youth in the United Kingdom has raised concerns well beyond its shores (full study) (1).  

The study surveyed over 9,000 children aged 11 -17 in England, Wales, and Scotland and found that 6 percent of those surveyed had used a tanning bed at one time, and another 15 percent of those surveyed had not used a tanning bed but felt they might do so in the future.  

Rates of use varied significantly by location, gender, age, and socioeconomic status.  Kids in the north tended to be more frequent users than those in the south.  Girls were more frequent users than boys.  Older kids more frequent users than younger kids; and those from lower socioeconomic groups more frequent user than those from higher groups.  Most notable were the extremely high rates in 15 - 17 year old girls in the cities of Liverpool and Sunderland , where rates reached upwards of 50 percent, the most striking evidence of a culture of tanning developing in the youth of the UK.

Exposure to UV radiation, particularly in youth and young adulthood, is a main cause of malignant melanoma - a particularly deadly form of skin cancer. And even though sunshine remains the most common source of UV exposure, tanning beds produce intense bouts of UV radiation and have been shown to independently raise melanoma risk (2).  With rates of malignant melanoma showing disturbing increases worldwide over the past decade, the results of the UK study are cause for alarm. 

One silver lining in the survey:  the youth who had not tanned said that health was a major reason for avoiding tanning beds.  Yet, this message is not having an impact on the behavior of all youth.  And with so much of the tanning bed use in the UK taking place in private homes or settings with inadequate supervision, youth are largely left on their own to make important decisions that can impact their long term health.

Moves toward mandatory restrictions on tanning bed use by minors under the age of 18 are gaining momentum in many countries, particularly Australia, which has been at the leading edge of sun and UV protection health campaigns.  Compelling policy papers have projected significant cost and health benefits and little downside to such restricted use in youth (3, 4).  

In the United States, rates of both developing and dying from melanoma are on the rise (5).  Partly in response to such troubling trends, the FDA has recently held hearings to consider tougher restrictions on tanning bed use.  The American Academy of Dermatology Association (AADA) - a public policy entity of the American Academy of Dermatology - goes so far as to support a total ban on tanning beds except for medical use.  Outside of an outright ban, the AADA recommends:
  1. Prohibiting access to indoor tanning for minors (under 18 years old)
  2. Educating all indoor tanning customers about the skin cancer risks and requiring their informed consent
  3. Implementing and enforcing labeling recommendations outlined in the Tanning Accountability and Notification (TAN) Act
  4. Encouraging enforcement of state regulations

The tanning bed industry is largely opposed to such regulation, and given the competing public and private interests, it's hard to know where the FDA will fall with tanning bed policy.  Voices in favor of greater regulation, though, are growing much much louder, and it's clear that steps that lower tanning bed use, particularly in minors, will go a long way toward lowering melanoma rates and improving the health of future generations.

Literature cited
  1. Thomson, C.S., et al., Sunbed use in children aged 11-17 in England: face to face quota sampling surveys in the National Prevalence Study and Six Cities Study. BMJ, 2010. 340: p. c877.
  2. World Health Organization (2003) Artificial tanning sunbeds: risk and guidance.  
  3. Hirst, N., et al., Estimation of avoidable skin cancers and cost-savings to government associated with regulation of the solarium industry in Australia. Health Policy, 2009. 89(3): p. 303-11.
  4. Gordon, L.G., et al., What impact would effective solarium regulation have in Australia? Med J Aust, 2008. 189(7): p. 375-8.
  5. Edwards, B.K., et al., Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer. 116(3): p. 544-73. (http://bit.ly/ccF9ma)