Key measures to focus cancer prevention
Several measures that are currently poorly defined in many of our studies that focus on prevention are now a priority for us to achieve the goal of preventing the majority of cancer. These are summarized below and in a recent article (http://bit.ly/aI2jAr)
Prevention Questions | Cohort | Methods issues |
Which exposure? | Refined measures | Validation and error correction strategies. |
Change by how much? | Observational cohorts ideally across broad range of exposure | Consortium adds value of broader exposure (e.g., EPIC and diet pooling project). |
Among whom? At what age must exposure be changed? | Level of exposure. Time course of exposure and disease development | Consortium adds power to evaluate effects of age. Intermediate endpoints refine temporal relations. |
How long must change be sustained? | Duration of altered exposure to modify cancer incidence | Repeated assessment, updating exposure, refines measures of duration and continuing adherence. |
Does risk reduction persist after cessation of exposure? | Updated exposure in cohort essential to address this question. | Follow-up of participants after intervention in trail setting adds insights here too. |
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